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Meta-inflammation promotes IR, hepatic steatosis, adipose tissue macrophage infiltration, and leptin resistance, creating a self-perpetuating cycle of metabolic dysfunction [2]
GLP-1s may additionally impact other physiological changes observed in the perimenopausal period, including vasomotor symptoms like hot flashes and night sweats, declines in bone health, and unhealthy changes in body composition (gains in fat mass and declines in muscle mass), but whether these impacts are beneficial or harmful for women's health remains unknown
518 A recent study found that the exercise-triggered striatal dopamine response was blunted in antibiotic-treated mice due to an increase in the levels of monoamine oxidase, the enzyme responsible for dopamine degradation
As an exploratory analysis, ANCOVA suggested that the elevation of these cerebral bile acids in DM mice (compared to NC) persisted after adjusting for body weight
Commonly experienced side effects can include menstrual irregularities in women, hypoglycemia (low blood sugar), autoimmune-like reactions such as itching or hives, and increased levels of lipase and amylase in the blood
V.TanrioeverG.KnigJ.RothS.et al (2020)
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