When exposed to a hyperglycemic milieu, the GIPR was found to downregulate in a study of pancreatic islet cells (59) and the patients with T2DM might express a small amount of GIPR or defective GIPR (60, 61)
If participants on CagriSema maintain higher energy expenditure after stopping treatment compared to participants on tirzepatide, the weight regain trajectory could differ meaningfully
Rodriguez-Flores EA, et al
Expert Supervision: Benefit from the experience of our nurse-led team who prioritise your safety
(2024) 6:e751e61
Systemic Side Effects Gastrointestinal Side Effects The most commonly reported side effects of GLP-1 RAs are gastrointestinal, including nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspepsia [113,114,115]