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These metabolic shifts help preserve high-energy phosphate reserves, minimize ischemic damage, and enhance ventricular recovery upon reperfusion (Ferrari et al

Notably, the benefits observed in these studies were largely driven by reductions in CV death, making SGLT2 inhibitors a critical component in improving overall survival rates in high-risk patients

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Step 2: Gradual Dose Escalation Treatment begins at a low starting dose, typically around 0.25 mg per week, increasing gradually every 4 weeks toward a maintenance dose often in the range of 1.7 mg to 2.4 mg weekly, depending on individual response and tolerance