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Some patients benefit from prophylactic anti-nausea medication during the first few weeks
Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, et al
& Masmiquel, L
This biased agonism refers to the fact that tirzepatide selectively engages cAMP signaling over -arrestin recruitment at the GLP-1R, which may augment cellular response via beneficial impact on GLP-1R cell surface trafficking, leading to increased cell surface expression
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