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hypothesized that elevated triglyceride (TG) levels could function both as a biomarker for major depression and as a contributor to its pathogenesis, possibly via dual pathways involving metabolic dysfunction and neuroinflammation ( In addition, ketone body (KB), a metabolite of TG in the liver, may also influence MDD ( Collectively, the evidence derived from both observational and mechanistic studies indicates a potential association between elevated triglyceride (TG) levels and depression, as systematically outlined in Table 1

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