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Clinical Studies and Findings Clinical studies show tirzepatides significant impact on inflammation reduction and metabolic health improvement

Cardiovasc Diabetol 17(1):83 European Medicines Agency (EMA) (2012) Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus European Medicines Agency (EMA) (2016) Reflection paper on assessment of cardiovascular safety profile of medicinal products Farah LX, Valentini V, Pessoa TD, Malnic G, McDonough AA, Girardi AC (2016) The physiological role of glucagon-like peptide-1 in the regulation of renal function

And all the guidelines recommend weight optimization