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Fang M, Wang D, Coresh J, Selvin E

In vitro effects of L-carnitine on coronary artery bypass grafts

The two -aminoisobutyric acid residues at positions 2 and 20 protect the peptide from DPP-4 cleavage and tune GIP receptor activity

They compared patients starting on GLP-1 RAs with those starting on SGLT-2 inhibitors, DPP-4 inhibitors, sulfonylurea, and basal insulin

HG: Visualization

This reflects the fact that GLP-1 agonists correct a physiological state (impaired satiety signaling and elevated ghrelin) that returns when the medication is removed

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