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In the vasculature, vitamin D deficiency promotes endothelial dysfunction by upregulating the expression of pro-oxidant NADPH oxidase and downregulating eNOS, reducing NO bioavailability (111)
Christopher Margrey, DVM
Gut microbiota-derived indole compounds attenuate metabolic dysfunction-associated steatotic liver disease by improving fat metabolism and inflammation
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Mechanistically, LONP1 silencing not only reduces cellular bioenergetic capacity but also decreases the LC3-II/I ratio and PINK1/Parkin levels, thereby suppressing mitophagy [169, 170] (Fig
The key driver of results is sustained supplementation over weeks rather than a single well-timed dose
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