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Slowed gastric motility from GLP-1 medications can make it significantly worse
The trade-off is that it also slows down the entire intestinal tract, including the colon
doi: 10.2147/IJGM.S15618 99 GhezziP.LemleyK
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A scrambled oligonucleotide sequence was used for specificity control (5- TTCTCCGAACGTGTCACGT-3)
The mechanism is distinct from PDE5 inhibitors (which act peripherally on vascular smooth muscle) and from hormonal treatments (which modulate circulating hormone levels)
Oral options expand choice and may improve real-world acceptance
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