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Research models also indicate modulation of NF-B signaling, with downstream effects on cytokine transcription in stimulated macrophage and fibroblast cultures

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237,238 Synphilin-1 also significantly decreases p53 expression and transcriptional activity and reduces p53 mRNA levels and p53 promoter transactivation, which are caused mainly by the production of C-terminal products through caspase-3-mediated cleavage

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