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Additionally, the TCGA database does not disclose whether patients are GLP-1 RA-exposed or -nave, thus future transcriptomic studies may comparatively investigate these patient populations across cancer types to further dissect immunogenomic differences

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Thus, in humans, GLP-1 action appears to be predominantly functional and anti-apoptotic rather than proliferative ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets

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