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Messlinger, K., Dostrovsky, J

Z., Chen, C., Zeng, Z., Yang, H., Oh, J., Chen, L., and Lu, S

Shaking introduces shearing forces that can physically break the peptide bonds or cause the molecule to denaturerendering it completely useless

That said, it should be viewed as a supportive tool within a broader skincare or wellness routine not a singular miracle fix

A reduced initial dose should be considered for patients known to be homozygous for the UGT1A1*28 allele However, the precise dose reduction in this patient population is not known Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Other polymorphisms of UGT due to random genetic differences have been reported, but only a few have suggested to influence drug metabolism in the clinic