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If an insurance plan has coverage for GLP-1 drugs, it is usually limited to patients meeting strict eligibility requirements as determined by a diagnosis of Type 2 diabetes, a track record of failing multiple previous treatments, and specific body mass index (BMI) criteriaand prior authorization is typically required

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Furthermore, impaired brain cholesterol synthesis can also enhance insulin resistance in brain tissue by disrupting the conformation of insulin receptor in cell membranes and promoting aberrant receptor activation (64)

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O (Outcome): Primary outcome: changes in serum Vitamin B12 levels, clinical improvement of Vitamin B12 deficiency symptoms

Importantly, no significant adverse effects were observed, and patients did not develop tolerance or rebound insomnia upon discontinuation