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Consistent findings have shown that GLP-1R agonism promotes weight loss and improves glucose homeostasis in rodents, monkeys and humans (reviewed in Barrera et al., The anatomical distribution of the endogenous GLP-1 system GLP-1 is derived from the preproglucagon gene

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5,6 GLP-1 drugs were made to mimic this hormone, meaning when you take them, they interact with the bodys GLP-receptors to suppress appetite, reduce hunger, and delay gastric emptying