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GLP-1s and Depression: Research Gaps Some of the uncertainty surrounding how GLP-1s influence mental health stems from early clinical trials

Evidence-based lifestyle interventions, including weight loss and dietary modification, remain the cornerstone of management

Pusceddu MM, Kelly P, Ariffin N, Cryan JF, Clarke G, Dinan TG

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This concern comes from early research

NO relaxes the inner muscles of the blood vessels (vasodilation), making them wider and better-able to push more blood, oxygen and performance nutrients (including L-Carnitine) to the working muscles (hence the pumping effect)