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Disruption of the barrier is referred to as 'leaky gut' or leaky gut wall syndrome and seems to be characterized by the release of bacterial metabolites and endotoxins, such as lipopolysaccharide (LPS), into the circulation

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Metabolic parameters including glucose tolerance, insulin sensitivity, and IGF-1 levels were monitored throughout the treatment period, confirming that the favorable metabolic profile persisted with chronic use

Collectively, these findings demonstrate that polyphenols and flavonoids act through a synergistic multi-target mode of action anti-inflammatory + antioxidant + anti-apoptoticwhich is more suitable for addressing the complex pathological processes of chronic inflammation compared to conventional single-target drugs