This arm produced the largest average weight loss but also the highest rate of gastrointestinal side effects
This broader activity is one reason researchers are interested in its potential metabolic effects
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On the other hand, the contribution of GLP-1R to BAT activation is likely secondary to G49 actions in the central nervous system (CNS) (i.e., Th mRNA) where GLP-1Rs are highly expressed in the hypothalamus 54 and to the activation of GLP-1R-mediated pancreatic insulin secretion-driven de novo lipogenesis and the subsequent series of metabolic events discussed above
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Ongoing research, including the semaglutide EVOKE trials in Alzheimer's disease, may provide more definitive evidence