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Factors such as the presence, number, and positioning of hydroxyl groups, saturation of the C-ring, and glycosylation status (the presence of sugar moieties) critically affect solubility and the capacity of flavonoids to cross cellular barriers in the intestine ( Hydroxyl Group Count and Positioning: Hydroxyl (-OH) groups attached to the aromatic rings of flavonoids influence their antioxidant properties, solubility, and polarity
While very high oral doses (1,000 to 2,000 mcg) can achieve some passive absorption without intrinsic factor roughly 1% of the dose is absorbed passively many clinicians prefer the reliability and rapid correction offered by injections in this population
Reduced Inflammation and Oxidative Damage Glutathione lowers chronic inflammation, minimising oxidative stress that contributes to various health conditions
You may read the shorter, opinionated editorial piece on my blog at drworldwide.com if youre more inclined to the lay public interpretation
& Tanaka, K
