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The patent application to further develop the nanobodies for clinical use and to attract industry partners has already been filed.

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The total impact score for each combination therapy was obtained by summing the individual pathway impact scores, calculated by the Disease Node Impact Score (as described in Section Estimating DM2 DMTs Drug Impact Effect Scores in the DM2-AD comorbidity network) for the pathways modulated by the respective drugs

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Magnesium can enhance the vasoactive effects of calcium-channel blockers, which may lead to a worsening hypotension

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Balancing these tangible costs against theoretical aspiration risks reinforces the need for pragmatic, patient-centered management rather than blanket cancellation policies

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