If constipation does not improve within a week of appropriate laxative use, or if red flag symptoms develop (such as rectal bleeding, unexplained weight loss, or severe pain), urgent medical review is essential
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Although tobacco use, alcohol use disorder, aspirin, NSAIDs, and family history were incorporated as PSM covariates and well balanced after matching, EHR-based capture rates for behavioral variables underestimate true prevalence, and residual confounding from unmeasured lifestyle factors cannot be fully excluded
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HRT addresses the hormonal environment that promotes weight gain
To calculate the sample size, it was considered a difference of 6 % ( 21 ) in the prevalence of oxidative stress in the groups with and without NAFLD, a power of 80 % and alpha of 5 %