doi: 10.1002/da.20505 62 MercerJ
As an example, Liu and co-workers designed a Fe 2+ -contained and PEG-modified nanocatalyst reacting with overexpressed H 2 O 2 to generate sufficient OH, which is able to kill tumor cells (Huo et al., 2019)
Any real effect would more plausibly be a triggered downstream cascade the peptide acting as a brief signal that sets something else in motion and the size of a trigger does not scale with effect the way a sedatives blood level does
This is the same principle behind why recombinant protein biologics (monoclonal antibodies, insulin analogues) are never shaken: air-water interfacial agitation unfolds polypeptide chains that then reassemble into non-native oligomers or fibrils
Coord Chem Rev 399:213022 Chowdhury MA (2017) Metal-organic-frameworks for biomedical applications in drug delivery, and as MRI contrast agents
By maintaining a healthy inflammatory response, glutathione protects the skin from further damage