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These peptides still require standard temperature and light precautions

Activation of the vascular smooth muscle GLP-1/NCX1 pathway regulates cytoplasmic Ca2+ homeostasis and improves blood pressure variability in hypertension

Honscheid A, Rink L, Haase H

Furthermore, the risk of hypoglycaemiaa major challenge when using insulinis reportedly lower with GLP-1RAs, given their glucose-dependent mechanism of modulating insulin release and glucagon suppression [25]

Healthcare professionals who encounter patients using unlicensed peptides should approach the conversation without judgement, document use carefully, and consider appropriate baseline investigations including liver function tests, lipid profile, and renal function

Outside of pregnancy, glucagon-like peptide-1 (GLP-1) receptor analogues have gained wide acceptance due to their efficacy and tolerability when compared to other treatment strategies