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Hormonal fluctuations during certain phases of the cycle may influence immune reactivity, potentially making injection site reactions more or less pronounced depending on timing

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Results Study Selection and Characteristics A total of 23 phase III randomized controlled trials met the inclusion criteria, contributing 48 treatment arms conducted exclusively in individuals with T2DM (see Table 1 for a summary of trial-level and treatment-arm characteristics, and Supplementary Table S1 for detailed study characteristics)