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Unlike gastroparesis cases where symptoms may improve after discontinuation, NAION results in irreversible optic nerve damage often described as an eye stroke, with no available treatment to restore lost vision
Early Clinical Results: In two small clinical studies, GLP-1 agonists reduced alcohol consumption and craving in patients with alcohol use disorder and reduced opioid craving by 40% among opioid use disorder patients 5 Bajaj, S
The SURPASS clinical trial program established its efficacy and safety profile in diverse patient populations with type 2 diabetes, while the SURMOUNT trials evaluated its effectiveness for weight management in individuals without diabetes
While dual receptor co-agonism offers enhanced weight loss and metabolic benefits, it also appears to offer upside in mitigating GI AEs
For example, a patient may respond well to a low dose of phentermine but need a slightly higher dose of topiramate to manage cravings and evening eating patterns
It may also reduce mobility and increase stress
