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With NNMT blocked, nicotinamide stays in the cell, NAD+ levels climb, and fat cells start burning more fuel instead of storing it

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This dual action creates a favorable metabolic environment for fat loss: increased breakdown of existing fat stores combined with reduced formation of new fat deposits

Inhibition of NNMT rebalances cellular methyl economy and NAD salvage flux, with downstream effects on adipocyte energetics, lipid handling, and insulin action observed in preclinical systems [13]

Body composition in DIO mice with/without NNMT inhibition showing reduced WAT mass with preserved lean mass relative to diet-matched controls [1,3,4]