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Mohammad Sarhan, MD, is an addiction medicine physician at Caron Drug and Alcohol Addiction Treatment Centers

A longitudinal clinical study in subjects at increased cardiovascular risk found that 6-month oral supplementation with acetyl-L-carnitine (2 g/day) significantly reduced arterial blood pressure and improved insulin sensitivity in insulin-resistant individuals, with effects progressively waning after treatment withdrawal

Pediatr Pathol Mol Med 18:471481

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Heart health : Glutathione reduces the harmful effects of oxidative stress that can cause heart disease

Direct Comparison Studies While large head-to-head trials specifically comparing these medications for weight loss are limited, the SUSTAIN 10 trial compared them for diabetes: SUSTAIN 10 results: Semaglutide 1mg vs