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TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions

One pool located outside of the mitochondria membrane and one pool located inside the mitochondria matrix

However, while they are recognized for their skin-lightening and brightening effects, the outcomes can vary and are not always predictable

This matters as a new cornerstone therapy in type 2 diabetes (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1), are entering broader use, necessitating a deeper dive into how this treatment interacts, directly or indirectly, with pathways influenced by sex hormones

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Peripheral neuropathy is also a leading cause of lower limb amputation in diabetic patients (68)