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Fortunato F, Martinelli D, Lo Caputo S, Santantonio T, Dattoli V, Lopalco PL, et al

35 Significant advances in pharmacological treatment have primarily focused on HFrEF, the current therapy for which is built on four key pillars: angiotensin receptorneprilysin inhibitor (ARNI) or, alternatively, ACE inhibitors or angiotensin receptor blockers

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Moreover, compensation for the loss of GLP-2R action, including by GLP-1R signaling, maintained expansion of intestinal length, weight, and preserved body weight gain in response to chronic cold stress