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While GLP-1 RAs offer promising therapeutic outcomes, clinicians must address potential challenges, including gastrointestinal side effects, contraindications (e.g., pregnancy, severe GI disorders), and risks associated with improper compounding practices (48)(540)
Naunyn-Schmiedeberg's Arch Pharmacol 398 , 26092625 (2025)
There was no evidence demonstrating other significant safety issue differences (e.g., serious AEs) between GLP-1RA plus SGLT2i combination therapy and either GLP-1RA or SGLT2i monotherapy [59]