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Incidence rate difference (IRD) and hazard ratio (HR) were estimated in the matched cohorts

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The pattern that emerges from this comprehensive comparison is that tirzepatide generally has a more favorable side effect profile for most categories, with the notable exceptions of injection site reactions and hair loss (which is weight-loss driven rather than drug-specific)

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By activating GLP-1 receptors in multiple locations throughout the body, these drugs slow gastric emptying (the rate at which food leaves the stomach), enhance feelings of satiety, and reduce appetite

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