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One stimulates the pituitary through GHRH pathways, while the other acts through ghrelin receptors, creating a broader signal for natural growth hormone release

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In addition, real-world use is frequently confounded by co-administration of multiple agents and inconsistent sourcing, limiting external validity and complicating attribution of benefit or harm

Growth hormone plays a critical role in preserving lean tissue, supporting recovery, and maintaining metabolic function during caloric restriction