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PubMed Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI

Time zone adjustments: If your injection day shifts by 12+ hours due to time zone changes, you can safely adjust by 12 days

Not only that but you end up with increased amounts of oxidants which have been linked to accelerate the ageing process

doi:10.1016/S0140-6736(13)62674-4

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Treatment usually begins with a lower dose to help your body adjust comfortably