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BJS open 10(2), 2026
As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner (49, 50) ( Figure 1D )
Thus, the leading causes of death in patients with thyroid dysfunctions are the consequences of atherosclerosis acceleration and the worsening of pre-existing cardiovascular and central nervous system diseases (77, 78)
10.1016/j.jenvman.2011.06.029 J
Of note, KD of ALOX15 and inhibition of 15LO1 decreased GPX4 protein expression, consistent with less need for peroxidase activity
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