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A practical detail for beginners: sermorelin has a very short half-life, on the order of minutes, which researchers have characterized in pharmacokinetic studies of GHRH(1-29)

Delayed Gastric Emptying: It slows down the speed at which food leaves your stomach

Altered Fat Distribution: The dip in oestrogen causes fat to accumulate more in the upper part of the body, particularly around organs and the waistline

Like any medication, and like all GLP-1 agonists, tirzepatide can have side effects

This distinguishes Ipamorelin from older GHRPs such as GHRP-6 (which strongly increases appetite and cortisol) and Hexarelin (which increases prolactin)

Muller, Dion, et al