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126 Particularly, central GLP-1R signaling may largely encode meal information, visceral organ signals relayed by vagal afferent transferred to the NTS, and circulation of limited GLP-1 to the ARC as well as other circumventricular organs, 86,127 whereas peripheral signaling may be transduced through local GLP-1R-induced neural-hormonal reflexes which influence insulin release or gastrointestinal motility

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