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According to one report, 3% to 43% of older adults living independently may have low serum vitamin B12 levels, especially those with conditions such as atrophic gastritis or pernicious anaemia

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Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025

Special population studies, including evaluation in elderly patients, patients with significant comorbidities, and patients with organ dysfunction, would help establish safety profiles for diverse clinical populations

For example, relaxin family peptides can alter gene expression via different signaling pathways

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