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Consistent with this, pharmacologic activation of NRF2 phenocopied the effects of melatonin, indicating that engagement of this pathway is sufficient to restrain ILC2 activity independently of melatonin itself

They analysed data of 50,815 adults with T2D who were new users of those drug classes: 16,619 started a GLP1 RA (median age, 58 years

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Alcohol can impair the liver's ability to produce glucose through gluconeogenesis, potentially prolonging or intensifying hypoglycaemic episodes

Therefore, therapeutic principles acting via different receptors and postreceptor pathways seem attractive in view of potentially additive or synergistic effects