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The exact mechanism isnt known, but constipation and fatigue are two common symptoms of low B12
Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions
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21 Mar 2013
Its status today is strictly research-only
Pooled trial data indicates the following side effects and their incidences [20]: Injection site reactions 24.5% Joint pain 13.3% Peripheral edema and limb pain 6.1% Muscle pain 5.5% Tingling sensations 4.8% Worsened glycemic control (elevated glycated hemoglobin) 4.5% Hypersensitivity (allergic reactions such as skin rash) 3.6% Carpal tunnel syndrome 1.5% Injection site reactions were the most common adverse reaction and mainly included pain, redness, and itchiness
