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Particularly, marionette lines, smile lines, deep nasolabial fold lines, crow's feet, fine lines/wrinkles, vertical lines between the eyebrows, horizontal forehead lines, sagging thin/frail skin, skin redness and dullness may be improved using compositions of the invention
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The peptide also modulates decorin expression, a proteoglycan that sequesters TGF- in the extracellular matrix
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