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Notably, FoxO1 is mainly responsible for regulating the expression of genes related to energy metabolism, while FoxO3a is more inclined to dominate the regulation of the genes related to autophagy and cell survival

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A 12-week multicenter randomized controlled trial provided strong evidence that for elderly people with sarcopenia or potential sarcopenia, the intervention of combined muscular-targeted oral nutritional supplements (rich in protein, HMB and vitamin D3) and structured exercise programs (including twin-weekly resistance training and interday chair exercises) compared with the control group It can more effectively improve the lean tissue of the limbs, skeletal muscle index, grip strength, walking speed, chair standing performance and quality of life [69]