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Pancreatitis was reported in 0.5% of Ozempic users and 0.8% of Saxenda users, compared to just 0.01% of those on Contrave

Focusing on evidence from human studies, we highlight how brain energy homeostasis, neurogenesis, synaptic functioning, neuroinflammation and other cellular stress responses, pathological protein aggregates, proteostasis, cerebrovascular system and blood-brain barrier dynamics may underlie GLP-1RA putative neuroprotective effects

Long-term safety data beyond four to five years are still emerging, leaving open questions about sustained muscle preservation, nutrient absorption, and lifelong dependence on medication

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