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It activates both glucose-dependent insulinotropic polypeptide receptors and glucagon-like peptide-1 receptors simultaneously, which produces stronger gastric motility suppression than semaglutide (a GLP-1-only agonist)

Wester A, Shang Y, Toresson Grip E, Matthews AA, Hagstrm H

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Current evidence suggests careful combination is possible, but timing, dosing, and individual variation matter significantly