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Proteins were released from nanoparticles (into the surrounding solution) when samples were incubated at 37C for 72 hours, but minimal protein release was observed at 4C (Figure 13)

These labs are often focused on bypassing hepatic first-pass metabolism or investigating central nervous system access in relation to hormone analogs

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Cells were treated with 100 ng/ml tunicamycin for indicated time

This could indirectly suggest that DPP-4 inhibitors may be less effective in pasireotide-induced hyperglycemia