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183 In addition, Small molecule antagonists which inhibit TGF- receptor kinase or TGF- activated pathways were studied, 184,185 although the long-term safety of such drugs might be a problem, particularly as TGF- affects tissue repair and is a potent anti-inflammatory mediator (Table 3)

Note that these outcomes were achieved in combination with diet and exercise, underlining the value of a holistic approach to weight loss and blood sugar management