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41 Yahui Zhang et al found that GLP-1RA can alleviate hyperinsulinemia and hyperandrogenism in PCOS mice by reducing inflammation of white adipose tissue and stimulating browning of white adipose tissue

T-cells are in an activated status (36)

Studies in GIP and GLP-1 receptor knockout (KO) mice have been undertaken in several studies to examine this role of the incretin hormones

This is supported by the observation that Tirzepatide (which also has GIP activity) consistently shows lower nausea rates than Wegovy despite producing more weight loss