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However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71

As far as CNS depression is concerned, the clinical observations do not suggest that carnitine is able to hasten the recovery of consciousness

yawning, stretching, and decreased appetite from central melanocortin activation Serious case reports : Priapism requiring medical management

Neurological injuries

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