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Discussion 1) The study completed by Zhang et al yielded several key findings regarding the role of FOXO4 in Leydig cell senescence and the therapeutic efficacy of FOXO4-DRI in alleviating age-related testosterone insufficiency

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50 An increase of testosterone, which was associated with a decrease in luteinising hormone (LH) and follicle-stimulating hormone (FSH), was also observed with NAC and selenium, individually and combined, in this study