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Observed RHR Increases in Clinical Data: + Liraglutide (1.8 mg daily): +610 bpm + Semaglutide (1.02.4 mg weekly): +24 bpm + Tirzepatide (515 mg weekly): +1.53.5 bpm + Exenatide (5-10 g Twice daily): +23 bpm A meta-analysis of over 60 randomized clinical trials found the mean RHR increase with GLP-1RAs to be 2.11 bpm (95% CI: 1.682.54)

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Safe consideration of peptides requires oversight, physician evaluation, and sourcing from regulated compounding pharmacies

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Current coverage for obesity medications is inconsistent, with most provinces covering GLP-1 medications for diabetes but not always for obesity alone

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Semaglutide vs Ozempic Availability As demand increases, Semaglutide vs Ozempic availability can fluctuate

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Insurance may reduce cost if medical criteria are met

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