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47 Large GWAS meta-analyses of BE and EAC have identified several novel risk loci, including CFTR (rs17451754, P = 4.8 10), MSRA (rs17749155, P = 5.2 10), TPPP and CEP72 (rs9918259, P = 3.2 10), TMOD1 (rs7852462, P = 1.5 10), FMNL2 (rs12987825, P = 3.88 10), SLC66A1L (rs60849513, P = 9.56 10 11 ), HTR3C and ABCC5 (rs9823696, P = 1.6 10)
GHK-Cu is a complex formed by the GHK tripeptide and a divalent copper ion (Cu)
These changes included mucosal erosion, ulcerative lesions, deformation and distortion of colonic recesses, extensive infiltration of inflammatory cells (primarily lymphocytes and neutrophils) in the mucosa and submucosa, and depletion of goblet cells
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doi: 10.1152/ajpcell.00946.2024 43 WangWLiLLiXChenJWangRYangQet al
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