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An intra-colonic injection of 180 mmol l 1 propionate (a total dose of ~0.45 mmol) vs saline control (matched for sodium content and pH) in anaesthetised rats resulted in a significant rise in circulating plasma PYY and GLP-1 levels (two-way ANOVA, effect of treatment P =0.024 and P =0.023, respectively)
During oxidative stress there is decrease in levels of GSH and increase in levels of GSSG and thus GSH/GSSG ratio decreases
Steroid-containing creams should not be used for prolonged periods because of their atrophic effects on skin
This reduces data noise and protects research validity
But, in some cases, like severe deficiency, shots might be given through a vein
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